This report documents the progress indicator (PI) process and analysis that Pacific Northwest National Laboratory (PNNL) developed to evaluate the potential energy savings from the application of ASHRAE Standard 90.1-2010 to building design and construction compared to the application of ASHRAE Standard 90.1-2004. The report describes PNNL’s EnergyPlus simulation framework, and the building prototype simulation models. The combined upgrades from ASHRAE Standard 90.1 -2004 to ASHRAE Standard 90.1-2010 are described, and consist of a total of 153 approved addenda (44 addenda to ASHRAE Standard 90.1-2007 and 109 addenda to ASHRAE Standard 90.1-2010). PNNL reviewed and considered all 153 addenda for quantitative analysis in the PI process. Fifty-three of those addenda are included in the quantitative analysis. This report provides information on the categorization of all of the addenda, a summary of the content, and a more in-depth explanation of the impact and modeling of the 53 identified addenda and their quantitative savings.